Institutes of clinical theory

Institute of General Practice

Director:

  • Prof. Dr. med. Hanna Kaduszkiewicz


The Institute of General Practice is supervised by eleven lecturers (since the winter semester 2010/2011), who are responsible for training students in the 9th, 10th and 11th semesters. The main task of the university lecturers in general practice is to teach medical students the special conditions of basic care as a general practitioner. Students therefore have the opportunity to familiarise themselves with typical patients in general practice, under real conditions.

The range of lectures on offer in general practice is also expanded and enriched by several lectures delivered by guest lecturers. There are 80 academic teaching clinics available for the practical block and practical year.

The teaching of general practice is the important link between university medicine and basic health care for the general population. It is therefore very important as more than 50 percent of German people attend their family doctor at least once a year.

Institute of Epidemiology

Director:

  • Prof. Dr. Wolfgang Lieb


The Institute of Epidemiology combines genetic epidemiological and classic epidemiological research within the context of chronic illnesses.

The fields of inflammatory diseases and cardiovascular diseases are particular areas of research focus. The Biobank popgen is an essential research resource that is located in the Institute of Epidemiology.

Kiel University and the Institute of Epidemiology participate jointly with the Universität zu Lübeck in the National Cohort (NaKo). The NaKo Study is a nationwide population study in Germany, with the aim of investigating the causes of widespread diseases of modern society, in order to be able to prevent them, detect them at an early stage and develop appropriate treatments.

Institute of Experimental Medicine

Directors:

  • Prof. Dr. John Baines - Evolutionary Genomics
  • Prof. Dr. Alena Buyx (deputy spokesperson) - Biomedical Ethics
  • Prof. Dr. Stefan Ehlers - Molecular Inflammation Medicine
  • Prof. Dr. Christoph Kaleta - Medizinische Systembiologie
  • PD Dr. Andreas Koch - Maritime Medicine Division
  • Prof. Dr. Andreas Tholey (spokesperson) - Systematic Proteomics

 
The Institute of Experimental Medicine (IEM) at Kiel University was established as part of the "Inflammation at Interfaces" Excellence Initiative and recently expanded to include a working group for ethics in medical science.

This group deals with a large number of duties in the area of research and teaching. The content and methodological orientation of the group is an important interface  between experimental and translational research and therefore between the laboratory and the clinic. As a result, the IEM operates as part of the research specialism "age-related mechanisms in the manifestation of diseases" spanning the three profile areas of inflammation, neurology and oncology.

The IEM's thematic focus is on investigations of influences known as "environmental factors" on the pathophysiology and pathogenesis of illnesses (including chronic inflammations, infections, autoimmune diseases and cancers). In other words, the influence of micro and macro milieus on the human organism.

Department of Experimental and Clinical Pharmacology

Director:

  • Prof. Dr. med. Dr. rer. nat. Ingolf Cascorbi


The Department of Experimental and Clinical Pharmacology researches the pharmacogenomics and epigenomics of drug metabolisms and membrane transport and the mechanisms associated with the origins of pain. Its other main focus is on the analysis of molecular interactions and function control and the pharmacological treatment of neurodegenerative illnesses and organ protection using antihypertensives.

The Department is part of the Cluster of Excellence 'Inflammation at Interfaces', the Krebszentrum Nord/Comprehensive Cancer Center, the P2N-Biobank and various international networks such as the Danish German InterRegIV Project MoMoTx and the International Severe Adverse Events Consortium (iSAEC). The Department also houses a unit for phase I clinical trials.

Specialities in health care are pharmacotherapy for physicians and pharmacists, in particular with regard to interactions and adverse effects of pharmaceuticals and pharmacogenetic diagnostics.

Institute of Experimental Cancer Research - Section for Molecular Oncology

Director:

  • Prof. Dr. Susanne Sebens


The Institute of Experimental Cancer Research (IET) was established in 2009 as part of the Krebszentrum Nord/Comprehensive Cancer Center within the framework of the application for an oncological centre of excellence. The Section for Molecular Oncology has been part of the IET since then. 

The Section began in the 1990s, as part of a research group located in the Department of General and Thoracic Surgery at the Kiel Campus of the UKSH. In 2004, the Section for Molecular Oncology was founded as a separate structural institution with the support of a Foundation Professorship of Deutsche Krebshilfe (German Cancer Aid).

The oncological Biobank BMB CCC is operated jointly with the Department of General Surgery, Abdominal, Thoracic, Transplantation and Paediatric Surgery and the Department of Pathology and is a member of the central biobank network (P2N) of the Faculty of Medicine. The P2N network is supported as part of the biobank initiative by the Federal Ministry of Education and Research.

Research is currently conducted in the causes of the formation, apoptosis resistance mechanisms and progression of gastrointestinal tumours. Oncogenic factors that we have recently discovered, known as death receptors, play a major role in this. The molecular biological diagnostics of the metastasis of these tumours is another research focus. Biomarkers are also useful here, to evaluate whether adjuvant treatment modes are indicated and their chances of success, and to set up corresponding, optimised, pre-clinical in vitro and in vivo model systems. This also occurs in close cooperation with the imaging centre MOIN-CC and the Cluster of Excellence 'Inflammation at Interfaces'.

Department of Human Genetics

acting Director:

  • PD Dr. med. Almuth Caliebe


The Department of Human Genetics, in co-operation with the associated Section of Human Genetics at the Medical Care Centre Kiel (Medizinisches Versorgungszentrum, MVZ), is responsible for the specialist human genetic care for large areas of Schleswig-Holstein. This covers the complete spectrum of human genetics from clinical genetics to genetic advice with regard to monogenic, multifactorial and epigenetic related diseases and on issues relating to prenatal diagnostics and human genetic laboratory diagnostics including cytogenetics, molecular cytogenetics, molecular genetics and epigenetics. The complete laboratory diagnostics are accredited in accordance with DIN EN ISO 15189.

Nationwide healthcare specialities are in molecular cytogenetic and array based diagnosis of syndromes with physical and intellectual disabilities and in genetic counselling in inherited tumour diseases. The department operates internationally recognised reference laboratories for genetic tumour analyses including lymphoma and leukaemia.

The Department of Human Genetics is integrated with the research interests of the faculty and is also part of the BMBF, EU and Deutscher Krebshilfe (German Cancer Aid) research networks, due to its research focus on somatic genetics (including tumour genetics), the detection of disease genes (e.g. in epilepsy), epigenetic definition of phenotypes and individualised prevention and treatment. It coordinates one of the German contributions to the International Cancer Genome Consortium (ICGC) and is the director of sub-projects in the Human Epigenome Consortium (HEP), in the Deutsches Zentrum für Lungenforschung (DZL, German Centre for Pulmonary Research) and in the „Imprinting-Erkrankungen“ (Imprinting Diseases) network. It is also integrated in systems biology networks, in particular with regard to malignant lymphomas.
In addition to the curricular education of students in Medicine, as well as Biochemistry/Molecular Biology and Medical Life Sciences, the Department of Human Genetics also offers complete Advanced Training to Consultant in Human Genetics for doctors, and to Specialist Human Geneticist for Scientists.

Institute of Immunology

Director:

  • Prof. Dr. Dieter Kabelitz


The Institute of Immunology conducts research in the fields of cellular and molecular immunology. It focuses on signal conduction pathways in cells and function analysis of human immune cell responses. Research scientists are members of the Cluster of Excellence 'Inflammation at Interfaces'. The Institute also operates flow cytometric cell sorting as a central platform and proteomic analysis using differential 2D gel electrophoresis.

In health care, the Institute has responsibility for flow cytometric laboratory diagnostics for the UKSH.  Furthermore, the Institute operates an outpatient department for couples with immunological infertility who wish to have children and carries out immunotherapy here.

Institute of Infection Medicine

Director:

  • Prof. Dr. Helmut Fickenscher


The Institute of Infection Medicine resulted from Kiel University's Institute of Hygiene which was established in 1888. The entire range of integrated clinical infection diagnostics is available to the direct Health Care service. Consultancy services on infectious diseases are also available.

The main research focus is on the molecular biology of infections with herpes viruses or hepatitis viruses, inflammatory reactions triggered by these and anti-infective defence mechanisms and treatment strategies.

Institute of Clinical Chemistry

Director:

  • Prof. Dr. med. Ralf Junker


The range of services provided at the Institute of Clinical Chemistry includes all modern laboratory medical procedures. A fully comprehensive medical laboratory diagnostics service is provided to the departments and external submitters of laboratory samples. This is carried out in close co-operation with the other institutes of the campus-wide diagnostic centre at the UKSH.

The Institute has four specialist areas which are characterised by a particular technical capacity and appropriate specialist expertise: coagulation diagnostics, auto-immune diagnostics, therapeutic drug-monitoring and clinical molecular biology.

Research in Clinical Chemistry is application-focused and aims for both continuous quality assurance and further improvements in laboratory diagnostics. In addition, scientists at the Institute carry out fundamental research focusing on hemostaseology, auto-immune diseases and health economics.

Institute of Clinical Molecular Biology

Director(s):

  • Prof. Dr. Stefan Schreiber
  • Prof. Dr. Philip Rosenstiel
  • Prof. Dr. Andre Franke


The Institute of Clinical Molecular Biology (IKMB) deals with the clinical implementation of molecular biological research approaches in the fields of chronic inflammatory diseases and gerontology. The Institute's scientific strategy in relation to this involves the evaluation of genetic variants and epigenetic mutations at the DNA level, the systematic evaluation of transcriptional regulation, the analysis of changes at protein level and understanding the function of relevant genetic signals. An important focus here is the characterisation of physiological and pathological interactions between epithelial barrier organs and colonising microbial flora (microbiom). The aim is to use research results in new, innovative treatments.

The Institute is part of both Clusters of Excellence 'Inflammation at Interfaces' and 'The Future Ocean' and the BMBF e:Med Netzwerk für System Medizin (Network for Systems Medicine) and in other research associations of the BMBF (IHEC, ICGC),  DFG (GRK 1743, CRC 877) and EU. It also has a close relationship with the Biobank Popgen and the Comprehensive Center for Inflammation Medicine ensuring an approach to research that is close to the patient.
Since the start of 2012 the IKMB is responsible for health care activities at the UKSH in the field of molecular genetic diagnostics and is affiliated with the Diagnostikzentrum (diagnostics centre) and the Institute of Clinical Chemistry.

Department of Medical Informatics and Statistic

Director:

  • Prof. Dr. Michael Krawczak


The Department of Medical Informatics and Statistic was established in 1964. Its areas of focus are in the fields of biometrics, medical statistics and epidemiology, in particular genetic epidemiology and population genetics.

Medical Informatics and Statistics at this specialist research institute is integrated into the teaching at the Faculty of Medicine. In addition, it offers services in the use and development of biometric and epidemiological procedures.

Department of Medical Psychology and Medical Sociology

Directors:

  • Prof. Dr. Michael Siniatchkin


The Department of Medical Psychology and Medical Sociology has been part of the Kiel Campus of the University Medical Center Schleswig-Holstein since 1987. The Department has been training medical students in the areas of Medical Psychology and Medical Sociology since 1972.

Its main scientific focus areas are in fundamental biopsychological investigations on information processing in the brain in the areas of pain, psychotraumatology and behavioural disorders in children and young people. Another area of focus is in the development and empirical evaluation of behavioural medicine prevention programmes in different disorders such as headaches, ADHS, obesity.

Department of Pathology

Director:

  • Prof. Dr. med. Christoph Röcken


The Department of Pathology is a nationally and internationally renowned department, whose Section for Haematopathology is part of the Kiel Lymphknotenregister (Lymph Node Registry), and whose Section for Paediatric Pathology is part of the Kiel Kindertumorregister (Paediatric Tumour Registry) and the Amyloid Register Kiel.

The main research areas are in the pathology and pathogenesis of malignant tumours in adults and children. The research is aimed at improving the early detection of malignant tumours using non-invasive methods and to be able to predict more accurately the biological behaviour (prognosis) and responses to treatment (prediction, individualised treatment) of malignant tumours.

The Department covers the entire spectrum of modern university pathologies in health care. This includes histopathology, cytopathology, immunopathology, molecular pathology and obductions pathology. It is involved in complete cell and tissue based diagnostics of human disease and of course the use of molecular diagnostics for the adjustment of target-oriented treatments.

The Amyloid Register Kiel is dedicated to conformational illnesses. It collects and documents cases with amyloidoses for research purposes, to develop new diagnostic and classification methods and to improve the treatment of amyloidoses.

Section for Haematopathology

Head of the Section:

  • Prof. Dr. Wolfram Klapper


The Section for Haematopathology and Lymph node registry is the birthplace of the "Kiel classification", created by Professor Karl Lennert, which was the first modern classification of malignant lymphomas. Diseases of the blood, bone marrow and the lymphatic tissues are diagnosed and researched in this Section, using the latest histopathological and molecular pathological methods.

The Section is a reference centre for all lymphoma studies for German researchers, nominated by the Competence Network Malignant Lymphomas and the leading reference pathology for paediatric non-Hodgkin's lymphoma (NHL- BFM), the Europäische Mantelzelllymphom Netzwerk (European mantle cell lymphoma network) and the German Hodgkin Study Group for low grade non-Hodgkin's lymphoma (GLSG).
 

Section for Paediatric Pathology

Head of the Section:

  • N.N.

 
The Section for Paediatric Pathology is the home of the Paediatric Tumour Registry of the German Society of Paediatric Oncology and Haematology (GPOH). This national reference centre was set up in 1977 and since then has reviewed around 50,000 tumour samples and examined them scientifically.

Each year, approx. 1,800 solid paediatric and young patient tumours are examined. These patients are primarily being treated as part of treatment optimisation studies run by the GPOH, but increasingly they originate from other European countries and from all over the world. On top of this, an increasing number of soft tissue sarcomas from adult patients are also examined. The tumour samples are classified and stage adjusted according to valid classifications and are also additionally investigated as part of biological follow-up programmes of treatment optimisation studies. The focus here is on soft tissue sarcomas, in particular rhabdomyosarcomas, nephroblastomas, malignant liver tumours and germ cell tumours, which are all analysed to determine their molecular genetic heterogeneity and the expression of treatment relevant proteins. The paediatric tumour registry receives financial support from the Deutsche Krebshilfe (German Cancer Aid).

Institute of Forensic Medicine

Director:

  • Prof. Dr. med. Johanna Preuß-Wössner


The first Institute of Forensic Medicine in Kiel was established in 1906 and was located in the Department of Pathology. The Institute of Forensic Medicine has been located in its own building since 1964. In 2000 the Institutes of Forensic Medicine in Kiel and Lübeck were merged and supply the public health system, the police and justice system in all of Schleswig-Holstein with forensic medical services. This includes autopsies, injury assessments, post-mortems, toxicological and DNA testing.

The main research focus is on the investigation of the ageing process at a molecular biological and protein level, the effects and genetics of drugs and the issue of "Medical Malpractice Errors and Iatrogenic Damage". The Institute of Forensic Medicine is a founding member of the Graduate School 'Human Development in Landscapes' of Kiel University.

Institute of Sexual Medicine and Forensic Psychiatry and Psychotherapy

Director:

  • Prof. Dr. med. Aglaja Stirn


The Insitute of Sexual Medicine and Forensic Psychiatry and Psychotherapy is affiliated with the Zentrum für Integrative Psychiatrie (ZIP - Centre for Integrative Psychiatry). Patients with the following disorders are treated at the institute:

  • female and male sexual dysfunction (e.g. low libido, erectile dysfunction, lubrication disorders, vaginisimus, premature ejaculation, orgasm disorders, increased sexual desires), also due to physical illness such as diabetes mellitus, Parkinsons, hormonal illnesses or because of relationship issues.
  • gender identity disorders (transsexualism, transvestitism, disorders of gender identity in children)
  • problems in discovering sexual identity (referred to as coming-out problems)
  • deviant sexual interests (paraphilia, such as paedophilia, exhibitionism or fetishism)
  • sexual abusive behaviour (stalking, sexual assault, rape)


The Institute's research areas are, on the one hand, the biopsychosocial foundations of human sexuality and, on the other, the causes of sexual disorders, which for the most part are still not fully understood. Our research is currently focused on neuroscientific investigations on paedophilia and the influence of higher cortical processes in response to sexual stimuli. The latter could help to clarify a huge range of clinical manifestations of human sexuality, from willingness to participate in prostitution, sexual dysfunction, to sexually abusive behaviours. The investigations are conducted using psychological questionnaires, reaction measurements on the genitals (phallometry and vaginal plethysmography), EEG and MRT.

The Institute offers four lectures to students of Medicine, Law, Psychology, Education and Biology: General and forensic sexual medicine (Parts 1 and 2), Biopsychosocial fundamentals of sexual orientation and gender identity (Parts 1 and 2). Students of Medicine and Psychology can obtain a Certificate in Sexual Medicine by also attending two seminars (Treatment of sexual disorders, Parts 1 and 2) and passing an oral examination.

Institute for Toxicology and Pharmacology for Natural Scientists

Director:

  • Prof. Dr. Edmund Maser


The Institute for Toxicology and Pharmacology for Natural Scientists is the only university institute for toxicology in Schleswig-Holstein. In addition to statements on current pollutants in the media, intensive research and teaching are carried out in the Institute.

The main research focuses on the molecular causes of conditions due to pollutants, whereby genetic predispositions and lifestyle factors are also taken into consideration.
Following intensive acquisition of research funding, the Institute now features the most modern methods and equipment and employs highly qualified scientists who network throughout the world. All ecotoxicological and human-toxicological subjects are taught to students of Medicine and Natural Sciences and also to the Faculty of Agricultural and Nutritional Sciences.